• The assessment process is even more difficult when Commercia

  2019-09-12

  

  The assessment process is even more difficult when Commercial-Off-The-Shelf (COTS) components – whose internals are partially or totally unknown – come into play. COTS are being increasingly used by the industry to reduce costs and to shorten development (and possibly deployment) time. However, sinc

• Because most fusion detection methods were developed to

  2019-09-12

  

  Because most fusion detection methods were developed to analyze paired-end reads (and especially Illumina data), they are not suitable for identifying fusion junction-spanning reads in single-end Ion Torrent libraries. Therefore, we developed the FusionDetect algorithm (implemented in the ChildDecod

• As for the molecular mechanism Ferguson BD suggested that

  2019-09-12

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of Cathepsin G Inhibitor I with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 ex

• br Experimental br Results br

  2019-09-11

  

  Experimental Results Discussion In the last two decades, several studies have shown an important role for progestogens, and in particular ALLO, in the modulation of Schwann cell physiology, regulating several biochemical and functional parameters. The classical PR has been found both in rat

• Although BPA has been proven to cause many health

  2019-09-11

  

  Although BPA has been proven to cause many health issues such as obesity and neurological toxicity (Rubin, 2011), the effects and mechanisms of BPA on the human tumorigenesis and cancer development are still not well illustrated. In the present study, we found that 10 to 10M BPA significantly promot

• Most xenobiotics undergo biotransformation before being excr

  2019-09-11

  

  Most xenobiotics undergo biotransformation before being excreted. Such biotransformation is classified into two phases. In the first phase, the lipophilic substrate is oxidized by the cytochrome P-450 (CYP450) enzyme system, which introduces a single oxygen Fructose Colorimetric/Fluorometric Assay K

• One question relates to our finding that

  2019-09-11

  

  One question relates to our finding that oxysterol-GPR183 signaling is critical for CP and ILF formation in the colon but dispensable in the small intestine. GPR183 and its ligand were expressed in both the small and large intestines. Moreover, 7α,25-OHC was required for ILC3 migration to CPs not on

• In addition to demonstrating the importance

  2019-09-11

  

  In addition to demonstrating the importance of DNMTs, we show that TGFβ1 differentially regulated DNMTs, and that TGFβ1 is both necessary and sufficient to induce lineage conversion of hepatocytes into MLCs with phenotypes and multipotency resembling MSCs. Upon withdrawal of TGFβ1 on day 28, we obse

• DAPK is involved in the p dependent

  2019-09-11

  

  DAPK-1 is involved in the p53 dependent apoptotic pathway and it is a mediator of γ-interferon induced apoptosis. DAPK-1 is also involved in other death signaling pathways (tumor necrosis factor-α, CD95 and transforming growth factor-β) and it blocks tumor metastasis in vivo. The loss of DAPK mRNA P

• Palliative surgeries for refractory epilepsy include vagus

  2019-09-11

  

  Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor

• br Methods Adult male B CRHtklee mice g at the

  2019-09-11

  

  Methods Adult male B6, 129 CRHtklee mice (25–30g at the beginning of the experiments) that were wild-type (CRF1R+/+) and recessive homozygous or knockout (CRF1R−/−) were housed six per cage. Mice were 3–5months old and derived from mating CRF1R+/− breeders (Jackson Laboratory, California). Wild-t

• Fmoc-Gly-OH kinase Mass spectrometry has previously been use

  2019-09-11

  

  Mass spectrometry has previously been used to examine the presence of Hyp in recombinant collagen, using hydrolysates to identify the individual imino acid, equivalent to an amino Fmoc-Gly-OH kinase analysis [33], and also by analysis of mass changes to tryptic peptides [34]. The present study, how

• Interestingly increased level of both circulating

  2019-09-11

  

  Interestingly, increased level of both circulating ET-1 and urinary excretion of ET-1 have been observed in patients treated with nephrotoxic immunosuppressive agents as cyclosporine A and tacrolimus (Slowinski et al., 2002). Other nephrotoxic agents, such as cisplatin, also increase urinary excreti

• In patients with CTEPH ET levels

  2019-09-11

  

  In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary Eplerenone clinical by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed in

• While these previous correlative studies have

  2019-09-10

  

  While these previous correlative studies have measured tDDR1 protein by IHC, these studies have not considered that pDDR1 could also be an important marker of cancer prognosis. A phosphoproteomic survey of lung cancer tissues did identify pDDR1 as one of the most commonly phosphorylated receptor kin

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