• Exon encodes a section of the extracellular ligand binding d

  2019-09-17

  

  Exon 3 encodes a section of the extracellular ligand-binding domain and two variants in the 5′ region were first identified in Drosophila melanogaster (Semenov and Pak, 1999). These variants were initially termed modules 1 and 2 and correspond to exons 3a and 3b, respectively. To date, exon 3 altern

• Here we examined whether Intracellular ER may

  2019-09-17

  

  Here, we examined whether Intracellular ER may mediate Cd-induced ovarian cancer proliferation. To determine this relationship, we used ICI 182,780 as a general inhibitor of ERα and ERβ. The results suggest a metalloestrogenic effect of Cd in ovarian cancer cell lines. Inconsistency with our results

• In silico modelling studies might aid our understanding of t

  2019-09-17

  

  In silico modelling studies might aid our understanding of the functionality and potential biological activity of food and, in the long-term they might underpin the development of personalised diets to reduce health risks and help us to better understand pharmaceutical/food interactions. Acknowle

• br Conclusions Two chemical coupling agents BTDE and CDI

  2019-09-17

  

  Conclusions Two chemical coupling agents, BTDE and CDI, were used to activate the free hydroxyl groups of plant cellulose powder and OPH from Flavobacterium ATCC 27551 immobilized on modified carriers by covalent linkages. The highest immobilization yields obtained in optimum conditions of effect

• In conclusion we have found that Egr can play

  2019-09-17

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response matrix metalloproteinase at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH

• br Concluding remark br Acknowledgements

  2019-09-17

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human Zinc protoporphyrin IX daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within

• In this study we examined a possible

  2019-09-17

  

  In this study, we examined a possible association between the 19-bp peptide receptors and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls using a case-control desig

• Ingested folate needs to be chemically modified in order to

  2019-09-17

  

  Ingested folate needs to be chemically modified in order to become a one carbon donor for cell metabolism. Firstly, folate turns to dihydrofolic Ciprofibrate and (DHF), it is then converted into tetrahydrofolate (THF) by the dihydrofolate reductase enzyme (DHFR) and finally converted into N5, N10-m

• Experimentally measured DGAT activity was first

  2019-09-17

  

  Experimentally measured DGAT activity was first reported by Weiss et al. (1960) and several different types of DGAT enzyme have since been described in plants [12,41,42]. As recently as 2011 there appeared to be just two DGAT enzymes both in plants and in other eukaryotes, namely DGAT1 and DGAT2 [43

• br Authors contributions br Acknowledgements br Introduction

  2019-09-17

  

  Authors’ contributions Acknowledgements Introduction Retinoic nitric oxide booster is a key signalling molecule in healthy development and in differentiation of stem cells, albeit uncontrolled levels of retinoic acid can lead to mutagenesis [1]. In eukaryotes retinoic acid is made by oxida

• vx 770 Our study demonstrated that the sequential events of

  2019-09-17

  

  Our study demonstrated that the sequential events of PKA and AMPK activation were involved in kinsenoside-mediated lipolysis. Within 1 h, PKA transiently inhibited AMPK activation by mitigating LKB1-mediated AMPK phosphorylation at Thr172, and PKA reduced AMPK-mediated phosphorylation at HSL-Ser565

• br Conflict of interest br Supplementary methods and

  2019-09-16

  

  Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F

• growth hormone secretagogue receptor Despite the weak and tr

  2019-09-16

  

  Despite the weak and transient nature of E2–E3 interactions, this binding is required for the transfer of ubiquitin to the substrate. The low affinity characteristics of this interaction may be due to the fact that E2s use the same surface to interact with E1s and E3s, and hence while binding to an

• Introduction The Discoidin Domain Receptors DDRs comprising

  2019-09-16

  

  Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RTKs) that function as microenvironmental sensors at the interface of the extracellular matrix and the intracellular signal transduction machinery [1]. In response to ligand

• N fowleri enters the host through the nasal cavity and

  2019-09-16

  

  N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the SU6668 where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits extensive damagin

15702 records 969/1047 page Previous Next First page 上5页 966967968969970 下5页 Last page