• Since the initial identification of DNA ligase

  2021-01-12

  

  Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the

• Preparation of the regioisomeric pyridooxazepinones and was

  2021-01-12

  

  Preparation of the regioisomeric pyridooxazepinones 10 and 11 was accomplished utilizing the synthetic sequence depicted in Scheme 3. Amide coupling of 63 and Cdk2/Cyclin Inhibitory Peptide I chloride 64 afforded amide 65. Removal of the alcohol protecting group, followed by base catalyzed cyclizat

• Resveratrol is a phytoalexin that occurs in relatively large

  2021-01-12

  

  Resveratrol is a phytoalexin that occurs in relatively large amounts in peanut, berries, grapes, and red wine (Soleas et al., 2001). A recent study showed that resveratrol prevents social deficit in an animal model of autism, indicating its potential for possible therapeutic use in children with aut

• The identification of a functional leucine

  2021-01-12

  

  The identification of a functional leucine-rich NES mediating 8E7 nuclear export led us to analyze the interaction between 8E7 and CRM1 nuclear export receptor. HeLa cell lysates containing EGFP-8E7, EGFP–8cE7, EGFP-16E7–NES (as a positive control), or EGFP (as a negative control) were incubated wit

• Previous studies have demonstrated the role of the COMT Val

  2021-01-12

  

  Previous studies have demonstrated the role of the COMT Val158Met in response to positive and negative emotional stimuli (Bouhuys et al., 1999, Cohn et al., 2009), a fundamental process involved in well-being (Diener et al., 2009a, Diener et al., 1999, Gross and John, 2003). A handful of studies rep

• Several of the plant extracts

  2021-01-12

  

  Several of the plant extracts that showed interaction with ERα and ERβ have differing reports concerning estrogenicity and receptor binding. Extracts of dong quai stimulated MCF-7 proliferation but failed to increase uterine weight or transactivate either ERα or ERβ in a cell assay (Amato et al., 20

• Progesterone s metabolite THP may also

  2021-01-12

  

  Progesterone's metabolite, 3α,5α-THP, may also be mediating burying and freezing responses. Results show female Long–Evans rats in behavioral estrous have higher P4 levels in serum, Cy3 NHS ester (non-sulfonated) receptor and hippocampus compared to diestrous female Long–Evans rats. Additionally, ov

• E cadherin is an adhesive Ca

  2021-01-11

  

  E-cadherin is an adhesive Ca2+ dependent transmembrane protein mediating tight and strong cell-cell adhesion through homophilic interactions. There is strong evidence in favour of the major role of E-cadherin in melanocytes adhesion to keratinocytes in the so much (Tang et al., 1994). The expressio

• The death associated protein kinase DAPK is

  2021-01-11

  

  The death-associated protein kinase (DAPK) is an actin-associated, calcium/calmodulin-dependent enzyme with serine/threonine kinase activity [11], [12]. DAPK is a pro-apoptotic gene and participates in various apoptotic systems, such as TNF-α- and Fas-triggered apoptosis [10], IFN-γ-induced cell dea

• Adenosine Kinase Inhibitor hydrate br Discussion In depressi

  2021-01-11

  

  Discussion In depression, an activation of the inflammation process and production of cytokines (including chemotactic cytokines – chemokines) and their receptors may occur due to the stimulation of the immune system. One of the earliest studied and described cytokines in depression is interleuki

• The CPA parameters of SO were

  2021-01-11

  

  The CPA parameters of SO2 were calculated based on Eq. (11) using the vapor pressure and saturated liquid density data of SO2 over the reduced temperature range of 0.55 to 0.9. All of the data used were taken from the NIST database [53]. The resulting CPA parameters of SO2 are presented in Table S1

• hcv protease inhibitor This study has several limitations Fi

  2021-01-11

  

  This study has several limitations. First, despite the relatively large number of participants for a pharmacological neuroimaging study, sample sizes for examining the modulation of THC effects by COMT hcv protease inhibitor were small. Therefore, these particular findings should be interpreted wit

• Located on the fore tarsals

  2021-01-11

  

  Located on the fore-tarsals of the front pair of legs, the Haller’s organ is presumed central to tick chemosensation. Recent genomic, transcriptomic and proteomic investigations have identified several families of transmembrane proteins in the forelegs of ticks that are likely involved in olfactory

• Among RAS mutant tumors analyzed we

  2021-01-11

  

  Among RAS mutant tumors analyzed, we found that the efficacy of either the SHP2 inhibitor SHP099, or combined MEK and SHP2 inhibition was best in those expressing RAS mutations at G12 (Figure 7B). Recent studies revealed that cellular RAS(G12C) activity depends on RTK-mediated nucleotide exchange, a

• br In half a century after its first biochemical

  2021-01-09

  

  In 2015–2016, half a century after its first biochemical characterization as a template-independent polymerase, it was shown that TdT can, firstly, assemble a DNA synapsis by itself, optimally with one micro-homology base-pair between strands [] and secondly, perform a template-dependent nucleotid

16186 records 756/1080 page Previous Next First page 上5页 756757758759760 下5页 Last page