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During pain signal transmission glutamate
2021-12-06
During pain signal transmission, glutamate is released into the synaptic cleft, which, in turn, causes activation of N-methyl-d-aspartate (NMDA) receptors and hence neurotransmission across the synapse occurs. The synaptic concentration and resultant activity of glutamate are controlled by excitator
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Introduction The brain contains abundant fatty acids which s
2021-12-06
Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial cells, suggesting that fatty acids play a crucial role in de
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br Material and methods br Results br Discussion
2021-12-06
Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a
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br Methods br Results Top panels of
2021-12-06
Methods Results Top panels of the Fig. 1 show the conventional representation of the predicted values of TL,CO according to ERS’93 and GLI′17 as a function of age and keeping the height constant (160 cm, panel A and 190 cm, panel B). This figure shows that the GLI-‘17 predicted values of TL,CO
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br Materials and methods br Results br Discussion Present
2021-12-06
Materials and methods Results Discussion Present study demonstrated the ability of a GIP agonist, D-Ala2GIP, to protect against the QA-induced neurobehavioral phenotype of HD in rats, for the first time. D-Ala2GIP treatment significantly improved the behavioral deficits, biochemical and neu
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In the liver ghrelin has opposite effects to
2021-12-06
In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty p-Cresyl sulfate receptor oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in a
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Since the Gardos channel Ca
2021-12-06
Since the Gardos channel Ca2+ sensor have been shown to be constitutively bound calmodulin [16] and the PMCA is activated by association to a calcium–calmodulin complex, it seems probable that the NS309 agonist effect is caused by direct interaction with the Gardos channel, and not by an action on c
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Since stroke and cerebrovascular diseases were considered se
2021-12-04
Since stroke and cerebrovascular diseases were considered serious AEs following vaccination, we performed manual chart review to confirm the diagnosis and symptom onset date for all stroke and cerebrovascular disease cases identified by ICD-9 codes. Chart review of 131 presumptive cases confirmed 82
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For many plasma membrane receptors
2021-12-03
For many plasma membrane receptors including GPCRs, their density on the cell-surface is finely controlled by various transcriptional, post-transcriptional and post-translational mechanisms, and is often a determinant of overall receptor function in a cell. To date, the transcriptional regulation an
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CC is a widespread disorder affecting up to of people
2021-12-03
CC is a widespread disorder affecting up to 20% of people worldwide, which also deteriorates the quality of life of patients and causes a substantial economic burden to society. There are 3 categories of CC: normal-transit constipation, slow-transit constipation and defecatory or rectal evacuation
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Immunohistochemistry using anti FFAR antibodies
2021-12-03
Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import
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The presence of FBP in nuclei
2021-12-03
The presence of FBP2 in nuclei seems to accompany the cells' potential to divide as it has been shown that during differentiation of the satellite cells (myogenic progenitor cells) the amount of nuclear FBP2 decreases and in differentiated myotubes, the localisation of FBP2 is restricted to cytoplas
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The ability to metastasize is the defining character
2021-12-03
The ability to metastasize is the defining character of a cancer and the leading cause for resultant mortality. It is hypothesized that a rare subset of cancer cells, often operationally referred to as “cancer stem cells” (CSCs), are responsible for sustaining cancer metastasis and recurrence [1]. T
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More specific quantitative assays for DiXaIs are based on th
2021-12-03
More specific quantitative assays for DiXaIs are based on the inhibition of chromogenic or clotting activity of Factor Xa. During drug development, Kubitza developed an endogenous Anti-Factor Xa assay [45], which is very sensitive to Rivaroxaban drug concentration. This assay was based on Factor Xa
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br Formation of secretory vesicles and trafficking
2021-12-03
Formation of secretory vesicles and trafficking toward plasma membrane Insulin and other components of the secretory granules are sorting and providing certain cues for lactacystin off the adjacent TGN membrane, forming immature secretory clathrin coated vesicles (Gehart and Ricci, 2013). Bin/Amp
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