• The concept of metronomic chemotherapy began in

  2019-06-28

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tu

• br Radiotherapy for bone metastases As a palliative interven

  2019-06-28

  

  Radiotherapy for bone metastases As a palliative intervention, radiotherapy is effective and efficient at treating painful bone metastases, and the side effects associated with its use are manageable and usually self-limiting in nature. Between 50% and 80% of patients gain at least partial relief

• MIP binds to three different receptors CCR

  2019-06-28

  

  MIP-1α binds to three different receptors: CCR1, CCR5 and CCR9. CCR1 and CCR5 are expressed on MM JNK-IN-8 and stromal cells. Inhibitors to CCR1 and CCR5 have been used to delineate the roles of each receptor in the myeloma bone marrow microenvironment[69]. Menu and colleagues demonstrated that MM

• Dexamethasone with its anti inflammatory properties has been

  2019-06-28

  

  Dexamethasone, with its anti-inflammatory properties, has been shown to be an effective medication in the treatment of pain flare and is hypothesized to prevent the phenomenon as well [12]. Despite a lack of literature investigating this hypothesis, currently published phase I and II trials have pro

• It is noted that in this study BrS

  2019-06-28

  

  It is noted that in this study BrS patients had an abnormality of plasma K+ concentration which has been suggested to be a potential trigger of Brugada Syndrome episodes [11]. In the absence of renal dysfunction, the hyperkalemia may result from an abnormal phenotype in BrS characterized by mutation

• A number of clinical studies have confirmed

  2019-06-28

  

  A number of clinical studies have confirmed the beneficial effect of ranolazine in either prevention or treatment of AF. The first strong evidence was provided by MERLIN-TIMI 36 trial [the Metabolic Efficiency With Ranolazine for Less Ischemia in Non–ST-Elevation Acute Coronary Syndrome–Thrombolysis

• The goals of Vision the global initiative to eliminate

  2019-06-28

  

  The goals of Vision 2020—the global initiative to eliminate avoidable blindness by 2020—include increasing cataract surgical rate and cataract surgical coverage. However, quality must not be sacrificed for quantity. The final visual outcome matters, both to the individual patient and to the communit

• Programmed death ligand PD L expression is a characteristic

  2019-06-27

  

  Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed

• All patients engrafted patient Patient developed secondary g

  2019-06-27

  

  All patients engrafted; 1 patient (Patient 6) developed secondary graft rejection following an A antigen mismatched graft from a male sibling and went on to receive a VUD HSCT with a female donor. There were no major conditioning related toxicities. Bacterial infections occurred in 6 patients prior

• L-Kynurenine br Risk of bleeding complications with dual ant

  2019-06-27

  

  Risk of bleeding complications with dual antiplatelet agents Dual antiplatelet therapy (DAPT) with combined aspirin and clopidogrel has become a standard treatment after percutaneous coronary intervention (PCI). Recent studies have examined the impact of such therapy on the incidence of bleeding

• Close inspection of the tumor matrix on

  2019-06-27

  

  Close inspection of the tumor matrix on the initial and subsequent 5 month radiographs (Fig. 7), shows an atypical appearance for osteoid matrix that adenosine deaminase may more closely resemble chondroid matrix. The matrix appears to display a linear dense lace-like pattern (Fig. 8). Of the only

• Effect of atorvastatin in modulation and protection of cardi

  2019-06-27

  

  Effect of atorvastatin in modulation and protection of cardiomyocyte ischemia and inflammatory phenomena (identified as a decline in perioperative CRP, hs-cTnT, and CPK-MB levels) [15,25–27] was not confirmed in the PROFACE trial. Because of no significant differences in the clinical preoperative or

• The congruence between BrS and ERS

  2019-06-27

  

  The congruence between BrS and ERS with respect to clinical manifestations and response to therapy lends further support to the repolarization hypothesis. Using an experimental model of ERS, Koncz et al. [30]. recently provided evidence in support of the hypothesis that, similar to the mechanism ope

• Competing pressures for resources across sectors however mea

  2019-06-27

  

  Competing pressures for resources across sectors, however, mean that increasing the proportion of resources for health will be difficult. Efficiency gains in the health sector could help to make the case for more investment. Countries need to tackle major sources of inefficiency by doing more of the

• El caso argentino sobre la literatura fant

  2019-06-27

  

  El caso argentino sobre la literatura fantástica puede ser interpretado de modo similar al de Mukarovsky, GW1929 propósito de la obra de arte como hecho semiológico (estético/social): por un lado, se encuentra el signo poético, que Macedonio y Borges recuperan en la obra literaria mediante sus cuent

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